Premium
Urinary Levels of Tumour Associated Antigens (CA 19‐9, TPAandCEA) in Patients with Neoplastic and Non‐neoplastic Urothelial Abnormalities
Author(s) -
CASETTA G.,
PIANA P.,
CAVALLINI A.,
VOTTERO M.,
TIZZANI A.
Publication year - 1993
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1993.tb06459.x
Subject(s) - neoplastic disease , antigen , medicine , neoplastic cell , urinary system , neoplastic transformation , pathology , cancer research , cancer , immunology , biology , carcinogenesis , cell , genetics
Summary— The urinary excretion of carbohydrate antigen 19‐9 (CA 19‐9), tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA) was evaluated in 264 patients with bladder cancer. Cut‐off levels were established using a pool of healthy blood donors. The combined determination of CA 19‐9 and TPA had a sensitivity of 74% in pTa and 83% in pT1 tumours, and 62% in grade 1, well differentiated tumours. Absence of disease at follow‐up was related to a significant decrease in CA 19‐9 and TPA in 129 patients with superficial (pTaorpTI) bladder carcinoma, followed up for at least 3 years. Recurrences, defined as new tumours at the same site or elsewhere in the bladder, were associated with an increase in the mean values but this was not statistically significant. A poor prognosis was indicated in patients with infiltrating tumours and the following pre‐operative levels: TPA > 1500 u/l or CA 19‐9 > 300 u/ml or CEA > 50 ng/ml.