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Search for Mycobacteria in Interstitial Cystitis Using Mycobacteria‐specific DNA Probes with Signal Amplication by Polymerase Chain Reaction
Author(s) -
HAMPSON S. J.,
CHRISTMAS T. J.,
MOSS M. T.
Publication year - 1993
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1993.tb00722.x
Subject(s) - interstitial cystitis , polymerase chain reaction , mycobacterium , dna , microbiology and biotechnology , pathology , biology , medicine , chemistry , gene , tuberculosis , genetics , alternative medicine
Summary— The aetiology of interstitial cystitis is not known. Various infective agents have been postulated and although recognised as perpetrators of chronic inflammatory conditions, mycobacteria have never been satisfactorily excluded from interstitial cystitis. If present in interstitial cystitis tissue, mycobacteria exist either in very small numbers or in forms which contemporary staining techniques fail to recognise. We used a polymerase chain reaction with mycobacteria‐specific DNA probes and found no evidence of mycobacterial involvement in 8 cases of proven interstitial cystitis.