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Treatment of Advanced Localised Prostatic Cancer by Orchiectomy, Radiotherapy, or Combined Treatment. A Medical Research Council Study
Author(s) -
FELLOWS G. J.,
CLARK P. B.,
BEY L. L.,
BOREHAM J.,
KEEN C.,
PARKINSON M. C.,
PETO R.,
WEBB J.N.
Publication year - 1992
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1992.tb15736.x
Subject(s) - medicine , orchiectomy , radiation therapy , urology , prostate cancer , surgery , cancer , oncology
Summary— A total of 277 patients with apparently localised prostatic cancer (T2‐T4 NXMO) were allocated at random to receive radiotherapy alone (88), orchiectomy alone (90) and combined therapy (99) between 1980 and 1985. The main outcome measures were survival, time to appearance of metastases and treatment of local disease progression by further transurethral resection. Orchiectomy, whether alone or with radiotherapy, produced a significant delay in detection of metastases when compared with radiotherapy alone. There were no statistically significant differences between the 3 treatment groups in local disease control or in overall survival.