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Agglomeration of Calcium Oxalate Monohydrate in Synthetic Urine
Author(s) -
GRASES F.,
MASÁROVÁ L.,
SÖHNEL O.,
COSTABAUZÁ A.
Publication year - 1992
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1992.tb15724.x
Subject(s) - agglomerate , economies of agglomeration , nucleation , calcium oxalate , precipitation , chemical engineering , chemistry , mucoprotein , scanning electron microscope , eutectic system , crystal (programming language) , crystallography , oxalate , materials science , mineralogy , inorganic chemistry , organic chemistry , biochemistry , microstructure , composite material , physics , meteorology , engineering , programming language , computer science
Summary— The development of agglomerated particles of calcium oxalate monohydrate (COM) on the semi‐batch precipitation from a synthetic urine carried out at physiological conditions (37°C, pH = 5.5) was studied by optical and electron scanning microscopy. COM agglomerates develop by primary and secondary agglomeration proceeding simultaneously; the latter mechanism is, however, less important than the former. Citrate ions modify slightly the COM crystal shape and inhibit primary agglomeration. Mucin particles serve as a substrate for preferential formation (nucleation) of new COM crystals. The structure of formed agglomerates closely resembles that of a certain type of COM renal calculi. A combination of primary agglomeration of crystals forming stones and nucleation of new crystals on a mucoprotein layer partially covering their surface constitutes the possible mechanism of such stone development. Experimental data support this mechanism.