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Vesicoureteric Reflux in Sibships
Author(s) -
UEHLING D. T.,
VLACH R. E.,
PAULI R. M.,
FRIEDMAN A. L.
Publication year - 1992
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1992.tb15604.x
Subject(s) - vesicoureteric reflux , penetrance , reflux , medicine , biology , genetics , pathology , gene , phenotype , disease
Summary— A family with 4 of 6 siblings manifesting vesicoureteric reflux is presented. Reflux could not be demonstrated in preceding and succeeding generations in this family. Genetic analysis suggests that most instances of familial vesicoureteric reflux arise secondary to expression of autosomal dominant single genes with incomplete penetrance. Screening of sibships for reflux might be most appropriately carried out by urine analysis, culture and ultrasound imaging.