Premium
Comparison of Effects following the Intracorporeal Injection of Papaverine and Prostaglandin E 1
Author(s) -
CHEN JANGKWANG,
HWANG THOMAS I. S.,
YANG CHIREI
Publication year - 1992
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1992.tb15568.x
Subject(s) - papaverine , medicine , prostaglandin e , significant difference , prostaglandin e1 , anesthesia , prostaglandin
Summary— A study group of 240 impotent men receiving intracorporeal injections were divided into 2 groups: the first group received papaverine (60 mg) and the second prostaglandin E 1 (PGE 1 20 μg). The effect of the drugs was evaluated according to the onset of erection, rigidity and the duration of erection; 136 patients were treated with papaverine and 104 with PGE 1 . The onset of action in these groups was 6.42 ± 5.39 vs 10.14 ± 5.41 min; the rigidity score was 3.37 ± 0.89 vs 3.60 ± 1.10 and the duration of erection was 49.56 ± 62.56 vs 63.60 ± 44.57 min respectively. There was a significant difference in the onset of action (PGE, was slower than papaverine) and maintenance of erection (longer with PGE 1 , than with papaverine). Another group of 17 patients received both papaverine and PGE 1 . The effects of papaverine were better in 4 cases, worse in 5 and equal to PGE 1 in 8. This study indicates that compared with papaverine, treatment with PGE 1 produces a slower onset of action, a longer duration of erection and fewer side effects.