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Comparison of DMSA Scintigraphy with Intravenous Urography for the Detection of Renal Scarring and its Correlation with Vesicoureteric Reflux
Author(s) -
ELISON B. S.,
TAYLOR D.,
WALL H.,
PEREIRA J. K.,
CAHILL S.,
ROSENBERG A. R.,
FARNSWORTH R. H.,
MURRAY I. P. C.
Publication year - 1992
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1992.tb15532.x
Subject(s) - vesicoureteric reflux , medicine , cystourethrography , intravenous urography , reflux , scintigraphy , urinary system , radiology , gold standard (test) , urology , nuclear medicine , pathology , disease , vesicoureteral reflux
Summary A series of 208 patients was prospectively assessed for reflux nephropathy by intravenous urography (IVU) and 99m Tc‐dimercaptosuccinate (DMSA) scintigraphy. All patients were studied at least 3 months after their most recent urinary tract infection and micturating cystourethrography (MCU) was performed prior to the scintigraphic studies. DMSA scintigraphy detected significantly more cortical abnormalities than did IVU. There was also a correlation between cortical abnormalities in the DMSA studies and the degree of reflux on MCU. The validity of DMSA as a cortical imaging agent is evaluated and the histological evidence for its efficacy derived from the animal model is reviewed, lending weight to its establishment as the “gold standard” for renal cortical scarring.