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Squamous Metaplasia in the Penile Urethra due to Oestrogen Therapy
Author(s) -
RUSSELL G. A.,
CROWLEY T.,
DALRYMPLE J. O.
Publication year - 1992
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1992.tb15529.x
Subject(s) - squamous metaplasia , urethra , asymptomatic , medicine , metaplasia , urology , immunohistochemistry , pathology , epithelium
Summary Histological examination was performed on the anterior penile urethra from 21 asymptomatic trans‐sexual patients taking oestrogens prior to surgery. Squamous metaplasia was present in 15 of these patients and in 1 man taking progesterones. Immunohistochemical staining for oestrogen receptors in the urethra was negative. Severe squamous metaplasia was associated with patchy chronic inflammatory cell infiltration but this was also present in normal controls. The lack of recognised complications of squamous metaplasia at this site suggests that it is an incidental observation in men taking oestrogens.