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Identification of Metastatic Disease by T Category, Gleason Score and Serum PSA Level in Patients with Carcinoma of the Prostate
Author(s) -
RANA A.,
KARAMANIS K.,
LUCAS M. G.,
CHISHOLM G. D.
Publication year - 1992
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1992.tb15528.x
Subject(s) - medicine , predictive value , prostate carcinoma , rectal examination , prostate specific antigen , oncology , prostate , disease , carcinoma , prostate cancer , urology , cancer
Summary Pre‐operative serum prostate specific antigen (Tandem‐R assay), T category, Gleason score and the metastatic (M 1) status of a consecutive series of 60 patients with newly diagnosed carcinoma of the prostate were studied prospectively. The results revealed that, of these variables, pre‐operative serum PSA (> 100 ng/ml) was the single most important indicator of metastatic disease, with 100% predictive value. With this alone, 83.3% of M1 disease could be correctly identified. For the remaining 17%, however, we advocate a high index of suspicion if the tumour is T3‐T4 category on digital rectal examination (predictive value = 71.4%) and has a high grade with a Gleason score 8–10 (predictive value = 81%).