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The Effect of Cromakalim on the Normal and Hyperreflexic Human Detrusor Muscle
Author(s) -
NURSE DIANE E.,
RESTORICK J. M.,
MUNDY A. R.
Publication year - 1991
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1991.tb15251.x
Subject(s) - cromakalim , detrusor muscle , detrusor instability , medicine , anesthesia , muscle contraction , chemistry , hyperreflexia , urinary bladder , pharmacology , agonist , urinary system , receptor
Summary Cromakalim is a benzopyran derivative which relaxes smooth muscle, probably by opening membrane potassium channels. This study tested the effect of cromakalim on spontaneous, electrically induced and pharmacologically induced contractile activity of normal and hyper‐reflexic human detrusor muscle samples. All 3 types of contractile activity were reduced in the presence of cromakalim. A preliminary clinical trial of cromakalim was conducted, the results of which also suggest that this type of drug may have a significant role in the treatment of detrusor instability and hyperreflexia.