Premium
Eicosanoid Synthesis in the Isolated Human Renal Pelvis, Ureter and Bladder
Author(s) -
ZWERGEL U.,
ZWERGEL Th.,
LEIS H. J.,
GLEISPACH H.,
ALEXANDRIDIS T.,
BELLETZ M.,
KIRSTEN R.
Publication year - 1991
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1991.tb15127.x
Subject(s) - renal pelvis , ureter , medicine , renal colic , prostaglandin , eicosanoid , urology , urinary system , pelvis , urinary bladder , smooth muscle , radioimmunoassay , endocrinology , chemistry , anatomy , pathology , arachidonic acid , biochemistry , alternative medicine , enzyme
Summary— Prostaglandin synthetase inhibitors are used for the treatment of ureteric colic. However, there is controversy regarding the mechanism of action of these drugs. In this study, differential prostaglandin synthesis in the human renal pelvis, ureter and bladder was measured using specific radioimmunoassays and gas chromatography/mass spectrometry. There was a significant quantitative predominance of the smooth muscle constrictor eicosanoids, PGF 2 a and TXA 2 over the dilatory PGE 2 in tissue from all sites–renal pelvis, ureter and bladder. The results indicate that prostaglandins play a direct role in smooth muscle activity of the upper urinary tract and the inhibition of this activity with indomethacin indicates a further mode of its action in pain relief in ureteric colic.