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Reduced Bladder Capacity in Patients Receiving Intravesical Chemoprophylaxis with Mitomycin C
Author(s) -
EIJSTEN A.,
KNÖNAGEL H.,
HOTZ E.,
BRÜTSCH H. P.,
HAURI D.
Publication year - 1990
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1990.tb14959.x
Subject(s) - cystectomy , mitomycin c , medicine , chemoprophylaxis , urology , bladder cancer , bladder neoplasm , surgery , resection , carcinoma , cancer
Summary— After complete resection of superficial bladder carcinoma (Tis‐2, G1‐3), 75 patients were treated prophylactically with either 20 or 30 mg mitomycin C. Six patients developed a substantial reduction in bladder capacity (less than 200 ml). In 2 patients radical cystectomy of an otherwise tumour‐free fibrotic bladder was necessary. The results of long‐term treatment (2 years) suggest that reduced bladder capacity correlates with the cumulative dosage of mitomycin C.