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Immunofluorescentand Histochemical Staining Confirm the Identification of the Many Diseases Called Interstitial Cystitis
Author(s) -
GILLESPIE LARRIAN,
SAID J.,
SOSTRIN S.,
KLEIWER K.
Publication year - 1990
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1990.tb14924.x
Subject(s) - staining , urothelium , interstitial cystitis , pathology , medicine , urinary bladder , alternative medicine
Summary— Interstitial cystitis comprises a complex of diseases typified by symptoms of pelvic pain. Functional complaints do not aid the clinician in determining loss of anatomical capacity. Histochemical staining with PAS‐colloidal iron/Van Geison's counterstain offers improved diagnostic ability for the pathologist and correlates well with immunofluorescent findings. Four distinct diseases can be identified through immunofluorescent staining, indicating that each is the result of different responses of the urothelium and endothelium to injury. Loss of bladder capacity associated with these diseases can be expected with age, but immunofluorescent staining for IgM within the capillaries of the interstitium is a more sensitive predictor.