Premium
Effect of Parenteral Oestrogen on the Coagulation System in Patients with Prostatic Carcinoma
Author(s) -
HENRIKSSON P.,
BLOMBÄCK M.,
ERIKSSON A.,
STEGE R.,
CARLSTRÖM K.
Publication year - 1990
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1990.tb14728.x
Subject(s) - medicine , coagulation , carcinoma , coagulation system , oncology
Summary— Patients with prostatic carcinoma on oral oestrogen therapy have an altered coagulation system and suffer cardiovascular side effects. Oestrogens—especially oral oestrogens—are potent inducers of liver synthesised proteins, including coagulation factors. We have assessed the effect of non‐oral oestrogen on the coagulation system in patients with prostatic carcinoma. Twelve patients were given monthly intramuscular injections of 320 mg polyoestradiol phosphate (PEP). No additional oestrogens were given. No change was found in any of the coagulation factors, including factor VII, with the exception of a significant decrease in antithrombin III. No patient, including 38 patients treated with PEP, had any cardiovascular complications after a mean follow‐up period of 12.9 ±0.7 months; 76% of the patients responded to treatment. Parenteral administration of oestrogen caused a less marked change in the coagulation system than oral administration and should be the treatment of choice for prostatic carcinoma.