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Megestrol Acetate in Relapsed Carcinoma of Prostate
Author(s) -
DANIEL F.,
MacLEOD P. M.,
TYRRELL C. J.
Publication year - 1990
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1990.tb14726.x
Subject(s) - megestrol acetate , medicine , megestrol , prostatic acid phosphatase , prostate carcinoma , urology , prostate , hormone , agonist , orchiectomy , carcinoma , estramustine , oncology , cancer , prostate disease , receptor
Summary— A series of 22 patients with advanced carcinoma of the prostate who had failed first‐line hormonal therapy (orchiectomy, stilboestrol, luteinising hormone‐releasing hormone agonist) were treated with 160 mg megestrol acetate daily. Treatment was well tolerated, side effects were minimal and 21 patients were evaluable. There were no complete or partial responses, although 8 patients had a good subjective response. In 6 patients the disease was stabilised for 6 to 12 months and there was a 40 to 50% reduction in their prostatic acid phosphatase (PAP) levels. It was concluded that megestrol acetate has a role as second‐line hormonal therapy in the management of prostatic carcinoma.