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The Effect of Verapamil on the Anti‐tumour Action of Mitozantrone and Doxorubicin against Renal Carcinoma Cells in vitro
Author(s) -
LAI TERESA,
MORGAN A. P.,
SMITH P. J. B.,
SYMES M. .
Publication year - 1990
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1990.tb07189.x
Subject(s) - verapamil , doxorubicin , pharmacology , in vitro , kidney , carcinoma , renal carcinoma , medicine , drug , long term potentiation , mechanism of action , chemistry , chemotherapy , calcium , biochemistry , receptor
Summary— Ten renal carcinomas were established in culture and their sensitivity to mitozantrone ± verapamil, as measured by (75 Se) selenomethionine incorporation, was studied. The 5 tumours with spread beyond the kidney were those in which sensitivity to mitozantrone was enhanced by verapamil. With 4 of the 10 tumours and 1 further carcinoma, similar experiments were performed using doxorubicin. This drug was more active, its anti‐tumour action being related to concentration. Verapamil was more effective in potentiation of doxorubicin and this action increased in proportion to the concentration of verapamil added.