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Excretion of Urinary Protein Induced by Extracorporeal Piezoelectric Lithotripsy
Author(s) -
BARAK M.,
GINESIN Y.,
HORNSTEIN L.,
LEVIN D. R.,
GRUENER N.
Publication year - 1990
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1990.tb07185.x
Subject(s) - excretion , extracorporeal , urology , lithotripsy , urinary system , medicine , surgery
Summary— An investigation was carried out into renal injury caused by extracorporeal piezoelectric lithotripsy (EPL) using an EDAP lithotriptor. Four urinary proteins, with a molecular weight range of 160000‐14500, immunoglobulin G (lgG), N‐acetyl‐beta‐glucosaminidase (NAG), albumin and lysozyme, were monitored in 27 patients 1 day before and 1, 7, 30, 90 and 180 days after unilateral EPL treatment. All patients had non‐obstructive renal stones, previously untreated. Apart from 5 patients with stablised hypertension and 6 with persistent urinary infections due to the infected stones, all patients appeared healthy, as confirmed by clinical, haematological and biochemical investigations. Only albumin levels increased significantly 1 day after treatment; statistically nonsignificant increases and decreases were recorded in the levels of NAG and lysozome respectively. IgG was beyond the limit of detection (< 0.5 mg%) in all patients. The albumin level returned to normal 7 days after treatment. The EPL‐induced increase in albumin was recorded in 88% of patients, compared with increased levels of NAG in 46% and lysozyme in 64%, mainly in those with infected stones. These findings indicated a transient glomerular injury after EPL treatment.