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Effect of Histamine on Human Vas Deferens in vitro
Author(s) -
LAU L. C.,
ADAIKAN P. G.,
RATNAM S. S.
Publication year - 1989
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1989.tb06057.x
Subject(s) - vas deferens , histamine , phentolamine , endocrinology , chemistry , mepyramine , guanethidine , medicine , histamine receptor , pharmacology , histaminergic , receptor , biology , stimulation , antagonist
Summary— Histamine, 2‐methylhistamine and 4‐methylhistamine produced concentration‐related contractions in some isolated human vas deferens preparations. The contractions produced by histamine and its analogues were reversibly and competitively antagonised by the H, ‐receptor blocker, mepyramine, but not the H 2 ‐receptor blockers, burimamide and cimetidine. Phentolamine, atropine and guanethidine did not affect the excitatory action of histamine. Histamine and 4‐methylhistamine did not show any inhibitory effect on KCl‐induced tone. The results showed that histamine receptors were present in the human vas deferens and the histamine receptors mediating the excitatory response were likely to be H 1 ‐receptors.