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Absorption of Drugs from Continent Caecal Reservoir for Urine
Author(s) -
EKMAN I.,
MANSSON W.,
NYBERG L.
Publication year - 1989
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1989.tb06054.x
Subject(s) - theophylline , terbutaline , urine , reabsorption , digoxin , absorption (acoustics) , drug , medicine , pharmacology , kidney , asthma , heart failure , physics , acoustics
Summary— The possibility of drug absorption from a continent caecal reservoir for urine was studied in 3 men with well functioning reservoirs. Saline solutions of digoxin, theophylline or terbutaline were instilled into the reservoir, each on a separate occasion, and drug concentrations in plasma and urine were measured for 24 h thereafter. Theophylline, but not terbutaline or digoxin, was absorbed from the reservoir. Estimated from an intravenous reference dose, the uptake of theophylline from the reservoir was approximately 50%. In patients with this type of urinary diversion, therefore, reabsorption from the continent caecal reservoir may complicate drug therapy.