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Inhibitory Effect of Pyrophosphate, Citrate, Magnesium and Chondroitin Sulphate in Calcium Oxalate Urolithiasis
Author(s) -
GRASES F.,
GENESTAR C.,
CONTE A.,
MARCH P.,
COSTABAUZA A.
Publication year - 1989
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1989.tb06004.x
Subject(s) - chemistry , pyrophosphate , magnesium , oxalate , calcium oxalate , chondroitin sulphate , calcium , inhibitory postsynaptic potential , urine , chondroitin , biochemistry , medicine , endocrinology , inorganic chemistry , enzyme , glycosaminoglycan , organic chemistry
Summary— The inhibitory capacity of pyrophosphate, citrate, magnesium and chondroitin sulphate was investigated, using the urine of 21 calcium oxalate stone‐forming patients without metabolic alterations. The inhibitory effect of these substances was assessed by a combination of nephelometry (light scattering) and optical microscopy. The results showed that citrate and magnesium had an inhibitory effect in a significant number of cases. Pyrophosphate and chondroitin sulphate had a less marked effect. The main urinary lithogenic biochemical parameters of the patients were also studied to see if there was a relationship between them and the inhibitory capacity of the compounds.