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Penile Response to Intracavernosal Vasoactive Intestinal Polypeptide Alone and in Combination with Other Vasoactive Agents
Author(s) -
KIELY E. A.,
BLOOM S. R.,
WILLIAMS GORDON
Publication year - 1989
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1989.tb05986.x
Subject(s) - papaverine , vasoactive intestinal peptide , phentolamine , vasoactive , tumescence , medicine , endocrinology , erectile dysfunction , stimulation , receptor , neuropeptide
Summary— Intracavernosally injected vasoactive intestinal polypeptide (VIP) (2 μg and 4 μg) resulted in penile tumescence even in men with predominantly organic impotence. Papaverine and phentolamine were successful in inducing erections in all subjects studied but the addition of VIP to this combination improved the erectile response further. A combination of papaverine and VIP produced penile rigidity similar to that with papaverine and phentolamine. While intracavernosal VIP alone produced disappointing penile responses, its combination with papaverine potentiated the response to this drug, probably by increasing venous outflow resistance.