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Urinary Oestrogen Excretion in Benign Prostatic Hyperplasia and Prostatic Cancer
Author(s) -
RANNIKKO S.,
ADLERCREUTZ H.,
HAAPIAINEN R.
Publication year - 1989
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1989.tb05982.x
Subject(s) - excretion , medicine , hyperplasia , endocrinology , estrogen , urinary system , cancer , carcinoma , endogeny , urology
Summary— Urinary oestrogen excretion was measured in 20 healthy middle‐aged men (controls), in 30 patients with benign prostatic hyperplasia (BPH) and in 32 prostatic cancer (PC) patients. The mean oestradiol (E2) excretion was significantly lower in the PC patients than in the controls and BPH patients. No other significant differences were found in oestrone (E1), oestriol (E3) and total oestrogen (E1 + E2 + E3) excretion between the 3 groups. The decreased E2 excretion in the PC patients is in accordance with our previous finding concerning significantly lower E2 plasma levels in PC patients. It seems possible that elderly men with lower endogenous oestrogen levels are at higher risk of developing cancer. On the other hand, the age‐dependent increased oestrogen levels may play an aetiological role in BPH.