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The Fine Structure of Human Pseudomembranous Trigonitis
Author(s) -
JOST S. P.,
GOSLING J. A.,
DIXON J. S.
Publication year - 1989
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1989.tb05279.x
Subject(s) - cytoplasm , urothelium , organelle , nucleolus , stratified squamous epithelium , biology , nucleus , microbiology and biotechnology , pathology , epithelium , anatomy , chemistry , medicine , urinary system
Summary— The present investigation provides a histological and fine structural description of pseudomembranous trigonitis, an ill‐understood metaplastic condition affecting particularly the female trigone. Normal trigonal urothelium consists of 3 cell layers (basal, intermediate and superficial), whereas pseudomembranous trigonitis constitutes many layers of stratified squamous epithelium. The basal cells contain prominent nuclei with condensed chromatin, nucleoli and nuclear bodies. The cytoplasm of these cells is rich in mitochondria. The profiles of the urothelial cells become progressively elongated, their nuclei increasingly smaller and their content of cell organelles gradually reduced as the luminal surface is approached. The squamous surface cells, linked by desmosomes, retain many longitudinally arranged fine filaments, together with an occasional degenerate nucleus. The mitotic index of pseudomembranous trigonitis is 0.17% (SD 0.09%), i.e. significantly higher than normal (0%).