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Possible Role of Tamm‐Horsfall Glycoprotein in Calcium Oxalate Crystallisation
Author(s) -
YOSHIOKA T.,
KOIDE T.,
UTSUNOMIYA M.,
ITATANI H.,
OKA T.,
SONODA T.
Publication year - 1989
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1989.tb05277.x
Subject(s) - calcium oxalate , crystallization , tamm–horsfall protein , macromolecule , calcium , chemistry , glycoprotein , oxalate , crystal (programming language) , urinary system , crystal growth , biochemistry , biophysics , crystallography , biology , inorganic chemistry , endocrinology , urine , organic chemistry , computer science , programming language
Summary— The role of Tamm‐Horsfall glycoprotein (THGP) in the crystallisation of calcium oxalate was investigated. The results showed THGP to have a weak inhibitory effect on crystal growth. In contrast, urinary macromolecules showed a strong inhibitory effect. THGP should, therefore, not be considered the main component of urinary macromolecules which have a strong inhibitory effect on crystal growth. However, THGP did enhance crystal production in the early phase of crystallisation. It appears that THGP should be viewed as a promoter rather than an inhibitor of calcium oxalate crystallisation at physiological concentrations.