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The Effect of Glycosaminoglycans on the Crystallisation of Calcium Oxalate
Author(s) -
KOHRI K.,
GARSIDE J.,
BLACKLOCK N. J.
Publication year - 1989
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1989.tb05250.x
Subject(s) - salt (chemistry) , crystallization , sodium oxalate , chemistry , calcium oxalate , glycosaminoglycan , nucleation , uronic acid , sodium , heparin , chondroitin sulfate , suspension (topology) , calcium , scanning electron microscope , nuclear chemistry , chromatography , oxalate , inorganic chemistry , biochemistry , materials science , polysaccharide , organic chemistry , mathematics , homotopy , pure mathematics , composite material
Summary— The effect of glycosaminoglycans on urinary stone formation was evaluated using a mixed suspension, mixed product removal (MSMPR) crystallisation system together with scanning electron microscopy (SEM) to examine the resulting crystals. Chondroitin sulphate was found to decrease the nucleation rate and to promote both the growth rate and suspension density. Results obtained with hyaluronic acid, although inconclusive, are similar to those given by chondroitin sulphate. Heparin sodium salt had a powerful inhibitory effect on both the nucleation rate and the suspension density, the effect increasing in proportion to the heparin concentration. SEM examination showed that the octahedral habit of calcium oxalate dihydrate was modified by the addition of heparin sodium salt and confirmed that the average crystal size in the presence of chondroitin sulphate and hyaluronic acid was significantly greater than the control or that found in the presence of heparin sodium salt.