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Leiomyosarcoma of the Kidney. Immunohistological and Ultrastructural Findings with Special Emphasis on the Growth Fraction
Author(s) -
KRECH R. H.,
LOY V.,
DIECKMANN K. P.,
GERDES J.,
STEIN H.
Publication year - 1989
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1989.tb05148.x
Subject(s) - leiomyosarcoma , immunostaining , pathology , ultrastructure , smooth muscle , mitosis , monoclonal antibody , leiomyoma , kidney , neoplasm , immunohistochemistry , medicine , biology , antibody , microbiology and biotechnology , immunology
Summary— This report deals with a case of renal smooth muscle tumour. Considering the low mitotic rate, this neoplasm would have been classified as leiomyoma. However, it displayed a relatively large growth fraction by immunostaining with the monoclonal antibody Ki‐67. This led us to the diagnosis “leiomyosarcoma”, which is in line with the unfavourable clinical course. We suggest that assessment of the growth fraction with Ki‐67 seems to be more objective than the conventional criteria for determining the malignant potential of smooth muscle tumours.