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Grading in Superficial Bladder Cancer. (2) Cytogenetic Classification
Author(s) -
PAUWELS R. P. E.,
SMEETS A. W. G. B.,
SCHAPERS R. F. M.,
GERAEDTS J. P. M.,
DEBRUYNE F. M.J.
Publication year - 1988
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1988.tb05061.x
Subject(s) - grading (engineering) , pathology , cytogenetics , bladder cancer , biology , chromosome , medicine , oncology , cancer , gene , genetics , ecology
Summary— Cytogenic analysis was performed in 92 newly diagnosed transitional cell bladder carcinomas and the results were correlated with the clinical course in superficial tumours. Low grade tumours appeared to have hypodiploid or peridiploid chromosomal numbers. Intermediate grade tumours were characterised by chromosomal counts up to the hyperdiploid range but could have a peridiploid modal number. In high grade tumours the modal number was hyperdiploid. The range in chromosomal counts appeared to be more reliable than the modal number as a predictor of the course of superficial tumours. The significant difference in chromosome numbers between low, intermediate and high grade tumours indicates that grading reflects major cytogenetic changes in the tumour cells.