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Controlled Trial of Intravesical Noxythiolin in the Prevention of Infection Following Outflow Tract Surgery
Author(s) -
JONES M. A.,
HASAN A.
Publication year - 1988
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1988.tb04354.x
Subject(s) - medicine , bacteriuria , surgery , incidence (geometry) , randomized controlled trial , complication , urinary system , urine , significant difference , catheter , anesthesia , urology , physics , optics
Summary— A randomised control trial was undertaken in 100 consecutive patients undergoing endoscopic surgery for outflow tract obstruction to assess the efficacy of noxythiolin in preventing post‐operative bacteriuria; 1% noxythiolin or sterile water was instilled at the time of catheter removal. The incidence of bacteriuria in the treated group (7/50) was significantly lower than in the control group (19/50). This was statistically significant. This difference was more marked in patients who had been catheterised for retention of urine. There was no difference in the complication rate despite a reduction of infection in the treated group.