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Prophylactic Treatment of Adult Nocturia with Bumetanide
Author(s) -
PEDERSEN P. A.,
JOHANSEN P. B.
Publication year - 1988
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1988.tb04294.x
Subject(s) - nocturia , bumetanide , medicine , chemistry , urinary system , cotransporter , organic chemistry , sodium
Summary— The efficacy of 1 mg bumetanide on nocturia was compared with placebo in a randomised double‐blind cross‐over study in general practice. Twenty‐eight patients, 13 females and 15 males, completed two treatment periods of 2 weeks' duration. During the placebo period the weekly number of nocturia episodes was 13.8 and during bumetanide treatment the number was reduced by 3.8. Ten males had a history of prostatic hypertrophy and in these patients treatment with bumetanide was not beneficial. In the remaining 18 patients the weekly number of nocturia episodes was reduced by 4 during bumetanide treatment compared with the placebo period. Of these patients, 3 preferred treatment with placebo, 11 preferred bumetanide and 4 gave no preference. These results suggest that bumetanide offers an alternative in the treatment of adult nocturia not connected with enlargement of the prostate.