Premium
Invasive Bladder Cancer. Should Patients who Respond to Radiotherapy be Treated by Cystectomy?
Author(s) -
LANGEMEYER T. N. M.,
PEER P. G. M.,
JANKEGT R. A.,
LEERS W. H.
Publication year - 1987
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1987.tb05492.x
Subject(s) - cystectomy , medicine , bladder cancer , radiation therapy , urology , surgery , retrospective cohort study , cancer
Summary— A retrospective study was carried out on the long‐term survival (5–12 years) of 160 patients with invasive transitional cell cancer of the bladder treated with irradiation between 1972 and 1980. Follwing 40 Gy irradiation of the lower abdomen, treatment consisted of cystectomy or continued irradiation of the bladder region only. A full urological examination of the baldder established whether a patient was arespondr or non‐responder. The patients were divided into four groups: 27 responders treatd with cystectomy and diversion; 48 responders treated with continued radiotherapy up to 65 Gy; 24 non‐responders treated with cystectomy and diversion; 42 non‐responders treated with continued radiotherapy up to 65 Gy. Survival and complications of treatment were compared with regard to category and grade of the tumours and sex and age of the patients. It was concluded that the responders who underwent cystectomy after 40 Gy irradiation survived longer than those who received a full course of radiotherapy. The responders had a better survival rate than non‐responders, regardles of further treatment. Salvage cystectomy was rarely carried out and proved to be an unsatisfactory alternative, with a high operative risk and short survival.