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Indoramin—an Effective New Drug in the Management of Bladder Outflow Obstruction
Author(s) -
IACOVOU J. W.,
DUNN M.
Publication year - 1987
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1987.tb05035.x
Subject(s) - medicine , placebo , anesthesia , adverse effect , drug , outflow , surgery , pharmacology , alternative medicine , pathology , physics , meteorology
Summary— There is a need for symptomatic relief in some patients with bladder outflow obstruction. The alpha blocker indoramin was tested in a prospective, double‐blind, placebo‐controlled trial. Thirty men were given indoramin or placebo. Flow rates and cystometrograms were performed before inclusion and at the end of 8 weeks' treatment. lndoramin gave significant relief of symptoms and dramatically improved peak flow rates. There were three withdrawals because of adverse effects and two withdrawals in the placebo group because of retention. Other side effects were either minor or transient.