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Bladder Instability and Denervation in Patients with Bladder Outflow Obstruction
Author(s) -
HARRISON S. C. W.,
HUNNAM G. R.,
FARMAN PAT,
FERGUSON D. R.,
DOYLE P. T.
Publication year - 1987
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1987.tb05033.x
Subject(s) - detrusor instability , denervation , detrusor muscle , medicine , urology , cholinergic , instability , smooth muscle , urinary bladder , anatomy , urinary incontinence , physics , mechanics
Summary— In vitro , pharmacological studies were performed on endoscopic detrusor biopsies from patients with bladder outflow obstruction. Urodynamic studies had been undertaken to detect the presence of bladder instability. Muscle strips from patients with instability demonstrated supersensitivity to acetylcholine and reduction in nerve mediated responses, as compared with strips from stable bladders. These changes are interpreted as suggesting the presence of cholinergic denervation in obstructed patients with bladder instability.