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The Effect of Pentosanpolysulphate and Carbenoxolone on Bacterial Adherence to the Injured Urothelium
Author(s) -
PANTAZOPOULOS D.,
LEGAKIS N.,
ANTONAKOPOULOS G.,
SOFRAS F.,
DIMOPOULOS C.
Publication year - 1987
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1987.tb04839.x
Subject(s) - urothelium , glycosaminoglycan , carbenoxolone , adhesion , chemistry , regeneration (biology) , microbiology and biotechnology , medicine , biology , urinary bladder , biochemistry , intracellular , gap junction , organic chemistry
Summary— The effect of the glycosaminoglycan (GAG) layer on the adherence of Escherichia coli to the bladder urothelium of rats has been studied. The study was performed by destroying the GAG layer and the changes were observed using the electron microscope. Bacterial adherence to the bladder with a destroyed GAG layer was much higher than to the normal bladder. Following the destruction of the GAG layer, the instillation of sodium pentosanpolysulphate significantly reduced the adhesion of bacteria. Prophylactic intramuscular administration of carbenoxolone increased the speed of regeneration of the destroyed GAG layer.