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Non‐cholinergic, Non‐adrenergic Nerve‐mediated Relaxation of Pig and Human Detrusor Muscle in vitro
Author(s) -
KLARSKOV P.
Publication year - 1987
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1987.tb04837.x
Subject(s) - detrusor muscle , cholinergic , adrenergic , relaxation (psychology) , muscle relaxation , stimulation , nerve stimulation , chemistry , endocrinology , basal (medicine) , medicine , smooth muscle , receptor , insulin
Summary— Previously unrecognised, nerve‐mediated relaxation in pig and human detrusor muscle is described. The relaxation was mediated via non‐cholinergic, non‐adrenergic and non‐prostaglandin transmitter or modulator systems and was present in 12 of 15 detrusor strips from six pigs and in four of 15 detrusor strips from seven patients. A contractile phase preceded relaxation in all strips; in contrast to the contractile phase, relaxation was augmented by an increase in basal tension in a complex way and possibly by the slowest stimulation frequencies.