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Aminoglutethimide in Advanced Prostatic Carcinoma
Author(s) -
HARNETT P. R.,
RAGHAVAN D.,
CATERSON I.,
PEARSON B.,
WATT H.,
TERIA.,
COATES A.,
COOREY G.
Publication year - 1987
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1987.tb04641.x
Subject(s) - aminoglutethimide , medicine , orchiectomy , gynecomastia , prostate cancer , urology , dehydroepiandrosterone , toxicity , prolactin , hormone , prostate , oncology , testosterone (patch) , cancer , endocrinology , breast cancer , aromatase , androgen
Summary— We have treated 34 patients with advanced prostate cancer, resistant to orchiectomy or oestrogen therapy, with aminoglutethimide. Seven patients (21%) showed improvement in pain and performance status for prolonged periods. By NPCP criteria six patients had stable disease and one had partial tumour response. Six of these patients remained on oestrogen therapy. Suppressed gonadotrophin levels (FSH and LH), despite orchiectomy, correlated strongly with benefit from aminoglutethimide. No relationships between response to treatment and changes in serum testosterone, dehydroepiandrosterone, oestradiol or prolactin were found. Six patients had side effects requiring cessation of therapy. A further 27 patients developed less severe toxicity. Despite its toxicity, these results show that aminoglutethimide has a role in the management of advanced prostatic cancer resistant to primary hormonal manipulation.