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Urinary Excretion of a Metabolite of Histamine (1,4‐methyl‐imidazole‐acetic‐acid) in Painful Bladder Disease
Author(s) -
HOLMBENTZEN M.,
SØNDERGAARD I.,
HALD T.
Publication year - 1987
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1987.tb04612.x
Subject(s) - urinary system , metabolite , urinary bladder , excretion , urine , interstitial cystitis , histamine , medicine , urology , endocrinology , gastroenterology
Summary— Thirteen patients with interstitial cystitis (detrusor mastocytosis) and 12 other patients with painful bladder disease without mastocytosis collected 24‐h urine specimens that were analysed for the major metabolite of histamine, 1,4‐methyl‐imidazole‐acetic‐acid (1,4‐MIAA), by reversed phase ion‐pair high performance liquid chromatography. The median urinary excretion of 1,4‐MIAA was 3.34 mg/24 h (range 1.47–4.66) in the patients with detrusor mastocytosis and 1.75 mg/24 h (range 0.18–4.30) in the other patients with a painful bladder (P<0.01). It was concluded from this study that patients with a painful bladder and detrusor mastocytosis had a significantly elevated urinary excretion of 1,4‐MIAA compared with other painful bladder patients without mastocytosis, whose urinary excretion of 1,4‐MIAA was within the normal range (0.72–2.34 mg/24 h). We suggest that the urinary excretion of 1,4‐MIAA might be useful in the diagnosis of interstitial cystitis.