Premium
Phenoxybenzamine in Prostatic Hypertrophy A Double‐blind Study
Author(s) -
FERRIE B. G.,
PATERSON P. J.
Publication year - 1987
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1987.tb04581.x
Subject(s) - phenoxybenzamine , urology , nocturia , medicine , placebo , urination , muscle hypertrophy , prostatectomy , urine , prostate , urinary system , pathology , alternative medicine , receptor , cancer
Summary— Forty‐five patients awaiting prostatectomy participated in a double‐blind study of phenoxybenzamine 10 mg/day for 5 weeks. Objective measurements of peak urine flow, voided volume, residual urine and frequency of micturition and nocturia showed no significant difference between phenoxybenzamine and placebo. Patients taking phenoxybenzamine had a significantly greater improvement in hesitancy and flow symptoms than those on placebo. Side effects occurred in 47.6% of patients on phenoxybenzamine and 22.2% of those on placebo. In this study phenoxybenzamine 10 mg/day was ineffective in patients with benign prostatic hypertrophy.