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Evaluation of Biopsy Techniques for Androgen Receptor Assay in Human Prostatic Tissue
Author(s) -
KYPRIANOU NATASHA,
WILLIAMS H.,
PEELING W. B.,
DAVIES P.,
GRIFFITHS K.
Publication year - 1986
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1986.tb05425.x
Subject(s) - androgen receptor , prostate , urology , receptor , transurethral resection of the prostate , androgen , resection , biopsy , medicine , prostate biopsy , radical retropubic prostatectomy , prostatectomy , andrology , endocrinology , pathology , prostate cancer , surgery , hormone , cancer
Summary— Androgen receptors were assayed in nuclei prepared from human benign hypertrophic prostate tissue obtained at retropubic prostatectomy by transurethral resection (TURP) and by cold punch resection. Androgen receptor was not detected in 70% of the transurethrally resected samples, and in those cases where receptors were observed they showed no correlation with enucleated samples. However, androgen receptors were detected in all cold punch resected samples and enucleated tissue with similar concentrations evident in samples from the same gland. These results suggest that prostate specimens collected by TURP are not suitable for androgen receptor analysis, whereas the technique of cold punch resection yields prostate samples that are more reliable for a correct evaluation of androgen receptor content.