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Inhibition of Spontaneous Contractile Activity in Isolated Human Detrusor Muscle Strips by Vasoactive Intestinal Polypeptide
Author(s) -
KINDER R. B.,
MUNDY A. R.
Publication year - 1985
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1985.tb08976.x
Subject(s) - vasoactive intestinal peptide , vasoactive , medicine , endocrinology , smooth muscle , muscle contraction , chemistry , neuropeptide , receptor
Summary— In a study of 75 isolated human detrusor muscle strips, spontaneous contractions and an associated sustained rise in basal tension were observed in 43 (57%). Vasoactive intestinal polypeptide (VIP) caused significant reductions in the frequency and amplitude of spontaneous contractions and a fall in basal tension. The results suggest that VIP may have a role as an inhibitor of spontaneous activity in the human detrusor.