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Flutamide Therapy for Advanced Prostatic Cancer: a Phase II Study
Author(s) -
MacFARLANE J. R.,
TOLLEY D. A.
Publication year - 1985
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1985.tb06415.x
Subject(s) - flutamide , antiandrogen , medicine , urology , hormone therapy , incidence (geometry) , cancer , oncology , prostate cancer , breast cancer , physics , optics , androgen receptor
Summary— A non‐steroidal antiandrogen (flutamide) was used to treat 17 patients with advanced prostatic cancer. Twelve of 14 patients who had already failed to respond to conventional hormone therapy were dead within 12 months of starting flutamide therapy and there was a high incidence of side effects. Of three patients who had not received prior hormone therapy, two showed an early partial response and one showed no evidence of response to therapy.