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Evaluation of the Efficacy of Oral Methotrexate in the Prevention of Recurrence of Superficial Bladder Tumours
Author(s) -
MARCH J. L. NOGUEIRA,
OJEA A.,
FIGUEIREDO L.,
JAMARDO D.,
DIEZ E.,
VILLANUEVA J. PEREZ
Publication year - 1985
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1985.tb06350.x
Subject(s) - thiotepa , medicine , methotrexate , surgery , cisplatin , transitional cell carcinoma , urinary bladder , urology , bladder neoplasm , oncology , bladder cancer , chemotherapy , cancer , cyclophosphamide
Summary— Twenty‐four patients with previously untreated TI transitional cell carcinoma of the bladder were treated with oral methotrexate 50 mg weekly for 18 months. Thirteen developed tumour recurrences (recurrence index 11 per 100 patient months at risk) and in one‐third of the patients treatment was stopped because of unwanted side effects. These results are no better than our previous experience with intravesical Adriamycin, thiotepa or cisplatin.