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Prostaglandin Synthetase Inhibition of Renal Pelvic Smooth Muscle in the Rabbit
Author(s) -
LUNDSTAM S.,
JONSSON O.,
KIHL B.,
PETTERSSON S.
Publication year - 1985
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1985.tb06294.x
Subject(s) - diclofenac , prostaglandin , diuresis , renal pelvis , prostaglandin e2 , renal colic , endocrinology , medicine , prostaglandins f , kidney , sulindac , pharmacology , nonsteroidal , pathology , alternative medicine
Summary— The prostaglandin synthetase inhibitors diclofenac and indomethacin relieve pain in renal colic probably by decreasing renal pelvic pressure. Decreased diuresis and effects on the oedema around the obstructing stone are plausible explanations. In the present study on rabbit renal pelvic tissue strips it was found that both indomethacin and diclofenac decreased the spontaneous phasic activity of the strips. ED 50 was 5.4 ±0.7 × 10 ‐5 M for indomethacin and 2.4 ±0.5 × 10 ‐5 M for diclofenac (P < 0.001). With the prostaglandin synthetase inhibitors still in the tissue bath the activity was regained when either prostaglandin E 2 or F 2α was added, prostaglandin E 2 being more potent in this respect. It was concluded that protaglandin synthetase inhibitors seem to reduce smooth muscle activity in the renal pelvis, a mechanism which might contribute to the pain‐relieving ability of these drugs in renal colic.