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Function of Human Autologous Kidney Grafts after Extracorporeal Preservation with Sacks' II Solution
Author(s) -
RANCH T.,
BRYNGER H.,
GRANERUS G.,
HENRIKSSON Ch.,
NILSON A. E.,
PETTERSSON S.
Publication year - 1985
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1985.tb06292.x
Subject(s) - autotransplantation , renal function , kidney , mannitol , urology , medicine , extracorporeal , beta 2 microglobulin , artificial kidney , parenchyma , surgery , chemistry , transplantation , pathology , biochemistry
Summary— The function of 18 human kidney grafts was studied before and 3 months after autotransplantation without prior bench surgery on the parenchyma or the vessels. Kidney protection was accomplished by pre‐treating the patient with mannitol and low molecular weight dextran solution and flushing the kidney with a Xylocaine‐heparin mixture and cold Sacks' II solution. The mean cold ischaemia time was 239 min (range 140–345 min). The glomerular filtration rate (GFR) remained unchanged post‐operatively in terms of both total and split kidney GFR. Proximal and distal tubular integrity, as studied by determination of beta 2 ‐microglobulin excretion and concentration ability respectively, was also preserved.