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Randomised Trial of Mesterolone versus Vitamin C for Male Infertility
Author(s) -
HARGREAVE T. B.,
KYLE K. F.,
BAXBY K.,
ROGERS A. C. N.,
SCOTT R.,
TOLLEY D. A.,
ABEL B. J.,
ORR P. S.,
ELTON R. A.
Publication year - 1984
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1984.tb06160.x
Subject(s) - medicine , infertility , fertility , pregnancy rate , pregnancy , gynecology , sperm , male infertility , testosterone (patch) , ovulation , significant difference , obstetrics , andrology , population , biology , hormone , genetics , environmental health
Summary— A prospective randomised trial was carried out to assess the effect of 9 months' treatment with either mesterolone or vitamin C in 368 men complaining of an infertile marriage. There was no significant difference in the wife's pregnancy rate between the two treatment groups. A separate analysis of the data was made to include only men with a low normal testosterone (< 16 nmol/l) and low sperm density (< 10 million/ml). This separate analysis was also restricted to men married to wives with normal test results for tubal patency and ovulation and again there was no difference in pregnancy rates between the two treatment groups. These results indicate that mesterolone therapy given in the absence of any defined endocrinopathy is of no benefit in promoting male fertility and furthermore we have been unable to find any subgroup who will respond. Improvements in the therapy of male infertility are only likely after a diagnosis has been defined.