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Calcium Excretion in Metastatic Prostatic Carcinoma
Author(s) -
GRAINGER R.,
REDA M.,
FITZPATRICK J. M.
Publication year - 1984
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1984.tb06147.x
Subject(s) - calcium , excretion , carcinoma , urology , medicine
Summary— In 64 men with prostatic carcinoma, calcium excretion per litre of glomerular filtrate (Ca e ) was persistently lower in those with bone secondaries than in those with soft tissue involvement only, despite a normal range of serum calcium in both groups. In three patients who showed an improvement in their bony metastases on bone scan 6 months after starting treatment, the Ca e values had increased slightly but still remained in the low range. In a further five who showed no improvement on bone scan, Ca e values were lower than before. In patients with prostatic carcinoma, Ca e is an indicator of early changes in calcium homeostasis. It may also provide an objective indication of progression of bone secondaries.