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Promotion of Bladder Tumours by Endoscopic Procedures in an Animal Model
Author(s) -
WALLACE D. M. A.,
SMITH J. H. F.,
BILLINGTON S.,
SMITH M. R.,
STEMPLEWSKI H. E.,
TIPTON P. W.
Publication year - 1984
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1984.tb06140.x
Subject(s) - animal model , saline , diathermy , medicine , carcinogen , urology , pathology , surgery , chemistry , organic chemistry
Summary— An experimental study was performed to assess the possible tumour‐promoting action of urothelial trauma caused by repeated intravesical diathermy, catheterisation, and the instillation of water, glycine and saline in the rat bladder which had previously been exposed to an initiating dose of the carcinogen N ‐methyl‐ N ‐nitrosourea. An increase in tumours and inflammatory changes was observed, especially in the group treated with water, and the significance of the findings is discussed.