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Changes in the Mucosa of Colon Conduits with Particular Reference to the Risk of Malignant Change
Author(s) -
MOORCRAFT J.,
DuBOULAY C. E. H.,
ISAACSON P.,
ATWELL J. D.
Publication year - 1983
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1983.tb06552.x
Subject(s) - medicine , electrical conduit , malignancy , inflammation , infiltration (hvac) , gastroenterology , pathology , surgery , mechanical engineering , physics , engineering , thermodynamics
Summary— Intestinal suction biopsies were obtaineid in 15 infants and children with cutaneous colo‐ureterostomies. The patients were subdivided into groups according to the length of time the conduit had been established, i.e . less than 5 years, 5 to 10 years, 10 to 15 years and over 15 years. The histological changes found were chronic inflammation with a dense infiltration of plasma cells and eosinophils. The changes were progressive and correlated with the length of time the conduit had been established. As persistent chronic inflammation is a precursor of malignancy, it seems likely that there is a risk of malignant change in these conduits. Regular follow‐up of such patients is recommended and should include flexible fibreoptic endoscopy of the conduit.