Premium
The Effect of Oral Acetohydroxamic Acid on Urinary Saturation in Stone‐forming Spinal Cord Patients
Author(s) -
BURR R. G.,
NUSEIBEH I.
Publication year - 1983
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1983.tb06545.x
Subject(s) - acetohydroxamic acid , urinary system , medicine , gastroenterology , urine , urology , chemistry , biochemistry , urease , enzyme
Summary— Chronic urinary infection is thought to be a major factor in the causation of urinary calculi in paraplegic patients. Acetohydroxamic acid is reported to be effective in some patients for the management of this type of stone disease, but there have been no studies of urinary saturation levels during therapy with this drug. In this study 10 patients received oral acetohydroxamic acid for seven days. Marked lowering of urinary pH and ammonium levels were observed, but decreases in urinary saturation were small. The administration of acetohydroxamic acid resulted in increased urinary excretion of magnesium and phosphate, effects that have not previously been reported.