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Potential Value of Antisera to Epithelial Membrane Antigen in Detecting Early Invasion in Transitional Cell Carcinoma
Author(s) -
POCOCK R. D.,
IBRAHIM S. K.,
SLOANE J. P.,
PONDER B. A. J.,
SHEARER R. J.
Publication year - 1983
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1983.tb03401.x
Subject(s) - urothelium , cytoplasm , staining , epithelium , antigen , biology , antiserum , stroma , pathology , positive staining , cell , immunocytochemistry , transitional cell , immunohistochemistry , transitional cell carcinoma , microbiology and biotechnology , cancer , immunology , anatomy , medicine , bladder cancer , genetics , urinary system
Summary— The distribution of epithelial membrane antigen in human transitional epithelium using immunocytochemical techniques was investigated. In inormal urothelium the antigen is restricted to the luminal surface and superficial cell cytoplasm. During neoplastic progression cytoplasmic staining of intermediate and basal cells is seen. In certain circumstances staining is seen at the interface between the stroma and tumour. The latter appearance correlates with the presence of invasion as assessed by conventional histology and may help to identify early invasion in difficult cases.