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Randomised Trial of Clomiphene Citrate Treatment and Vitamin C for Male Infertility
Author(s) -
ABEL SCOTTISH INFERTILITY GROUP B. J.,
CARSWELL G.,
ELTON R.,
HARGREAVE T. B.,
KYLE K.,
ORR S.,
ROGERS A.,
BAXBY K.,
YATES A.
Publication year - 1982
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1982.tb13647.x
Subject(s) - infertility , allowance (engineering) , medicine , male infertility , gynecology , dose , significant difference , pregnancy rate , pregnancy , sperm , oligospermia , randomized controlled trial , obstetrics , andrology , biology , mechanical engineering , genetics , engineering
Summary— A prospective randomised trial was carried out to assess the effect of 6 months' treatment with either clomiphene citrate or vitamin C in 179 men complaining of infertile marriage. There was no significant difference in the wife's pregnancy rates between the 2 treatment groups. In order to detect a subgroup that might respond to clomiphene the results were analysed according to pre‐treatment FSH and sperm density, with allowance being made for the result of the wife's tests, but still there was no significant difference in treatment response. Vitamin C would seem a preferable and cheaper alternative treatment for male infertility.